Sahm Adrangi Is Onto Another Biotech Firm, Proteostasis, Calling Out Their New Drug Results

Kerrisdale Capital issued a negative report last week on the biotech firm, Proteostasis. Proteostasis recently made claims of developing a new drug for cystic fibrosis patients that is able to increase lung performance dramatically. Though the data they have presented is not very good and they have been highly transparent in their testing. This is what urged Sahm Adrangi to do some digging on the company, allowing Kerrisdale analysts to go over the data. Sahm Adrangi is a high-profile investor that has tackled other problem companies in the past and to great success actually. His reputation is good and many in the business world are ready to follow his lead, especially other investors to his successful track record.

This new drug that is being produced by Proteostasis had an extremely small sample size, consisting of just four individuals. For a disease like cystic fibrosis, claiming to have made a breakthrough is a big thing, and this is shattered when looking at the true data, which isn’t in good shape to begin with. According to Sahm Adrangi, Proteostasis’ has very messy data that cannot be understood easily. There results that have announced aren’t even accurate in their own data. With a sample size of four patients, results are skewed and possible just placebo. For a biotech company, offering data that has no actual information or results to be seen is a very bad thing. Whether its due to poor testing or bad management, either way, it’s shady for the business.

Sahm Adrangi’s statements and the report issued by Kerrisdale has had a noticeable impact on Proteostasis already, causing their share value to dip more than 15 percent since the report was released. This also caused the biotech firm to sell nine million of their own shares to recoup money for their continued testing. With that said, Proteostasis currently has more than 70 percent of their stock value invested in their drug, which could prove fatal for the company if it is not effective for patients.


Clay Siegall is a founding father of Seattle Genetics, its President from June 2000 and its CEO from November 2002. The company was founded in 1998 had has had its operations around Human antibodies manipulation, study and eventually their packaging into drugs. Its connection ability with something else, e.g. therapy, provides their antibodies power just as Lego bricks do. An antibody destroys a cancer cell from the inside once it delivers a payload of toxic. This strategy could have Seattle Genetics catapulted into the community of Seattle’s biotech, a pharmaceutical company that it has long sought to anchor by overcoming the many ups and downs plaguing the sector.

Seattle Genetics has been ranked the largest Washington biotech with its market value approaching $10 billion and a list of 900 employees. It highly invests in marketing and research to achieve its ambition to be one of the companies that move to Pharma from biotech. Its flagship drug, Adcetris, treats a lymph system cancer that spreads from one organ to another. This cancer is referred to as Hodgkin lymphoma. The tests on the drug done in 2017 will have its tests take off if the results come out positive.

Clay Siegall said that the company was going global, oncology and multiproduct with proving from their long drugs list. He adds that all that he wants is to build a company that is great rather than selling their drugs to larger companies as is the case with other biotech firms. Information on global markets learned from the company’s partnership with Takeda has also made him have an office opened in Switzerland to allow for international marketing.

Clay Siegall’s experience of around 20years in development of therapeutic drug and cancer research has helped him in leading Seattle Genetics. He has led this company into a diverse field of cancer therapies based on antibodies including brentuximab vedotin or adcetri, that the United States FDA hurriedly approved in 2011. He has also led this company into capital-raising activities that have had it secure more than $670 million through private and public funding. Before Seattle Genetics co-founding, he worked with Bristol-Myers Squibb Research Institute of Pharmaceuticals in 1991 to 1997 and in the Health National Institute with the Cancer National Institute from 1988 to 1991. He also serves on Alder Biopharmaceuticals directors’ board as a member. He holds fifteen patents and has over 70 publications under his name. He got his Genetics PhD from Washington University and his Zoology B.S. from Maryland University.

Talkspace for Your Therapy Needs

Being able to receive therapy can help any number of mental health disorders. Many people nowadays are living with severe PTSD and are struggling to make their life work. If you’re experiencing a shift in the way that you feel, it is time to get therapy and be able to talk to a qualified professional. The way that a therapist works is by having you sit down with them and talking about the unique problems that you’re experiencing right now. They will then walk you through different processes of handling these issues so that you can reclaim your life. You will find that conventional therapy is difficult for a lot of different reasons. For one, therapists might be too far away from where you live, so it’s too inconvenient to get there weekly for your appointment. Other times, people just don’t connect to the therapist they’re assigned to.

If you want a better option, Talkspace is the one for you and can be used right from home. In fact, all you need to do to make use of Talkspace is to download their app to your mobile device. Most mobile devices support Talkspace and are easy to use for your needs. Once you download Talkspace to your phone, you’ll be matched with a therapist who is available to you when you need it. You can message them and even video chat with them to have a face to face conversation.

There are lots of people right now using Talkspace with amazing luck and success. In fact, a lot of doctors are now recommending Talkspace because of the convenience that happens to be involved. Before going to your nearby therapist and seeing if they can help, you might want to consider Talkspace and give it a try on your own mobile device.


Heal N Soothe Heals From the Inside Out

Heal N Soothe is a natural pain fighter that does not contain any ingredient derived from animal products. Instead, this product is made form all-natural ingredients such as ginger, proteolytic enzymes, bromelain, turmeric extract, papain, devil’s claw, boswellia extract, vitamin E, rutin, L-glutathione, citrus bioflavonoids, and Mojave yucca root.

Many people turn to prescription or over-the-counter drugs to deal with their pain, but these products simply mask the underlying issues. Many painkillers also come with unwanted and even dangerous side effects. Since Heal N Soothe is a completely natural product it does not comes with nasty side effects and it does not harm any animals in the manufacturing process.

Heal N Soothe is a daily supplement that works hard to heal the body form the inside out and even helps to reduce the damage caused by the toils of life as it is taken over time. Heal N Soothe contains systemic proteolytic enzymes that benefit the body in many different ways. These enzymes help to break down scar tissue, cleanse the blood, strengthen the immune system, and improve the body’s functions such as its immune system and respiratory and cardiovascular functions. The longer the supplements are taken, the more time these enzymes have to work throughout the body to heal and recover.

Heal N Soothe helps the body to get relief from pain and swelling as it also helps the body to recover much more rapidly from things such as surgery, bruises, sprains, fractures, contusions, strains, and joint pain.

Heal N Soothe can be purchased for about $50 on eBay, Amazon, or on the Heal N Soothe website and one bottle will last about one month. It is a very affordable way to safely manage pain. Heal N Soothe also offers a membership program and a free 30-day trial to its newest members, so there is nothing to lose. Most people who use this product find that they notice a significant improvement in as few as two weeks, but everyone is different and have different levels of pain and inflammation. All it takes to notice the benefits of this product is taking a supplement or two a day. The dosage can easily be adjusted to each individual as well.

Heal N Soothe is ideal for anyone wanting to get relief form pain and inflammation naturally and without side effects. It is a pretty effortless way to get relief from discomfort.

Jeff Herman – Wants Abused Children to be Heard

Child sexual abuse is a national issue, and throughout the country, legislators are rewriting, discarding, or introducing new legislation to protect children and others who are victims of sexual abuse. The State of New York has introduced a Senate bill, S.809 that will dramatically rewrite New York statutes regarding the issue of child abuse. Known as the Child Victims Act, the bill introduced by Brad Hoylman who represents Manhattan would effectively eliminate both the criminal and civil statutes of limitations, extending the window to bring civil action lawsuits before the courts from one year to 50 years.
A coalition of New Yorkers called “New Yorkers Against Hidden Predators” received a boost in their efforts to get the legislation passed when two high-profile individuals joined their cause. Actor Corey Feldman and Team USA volleyball player Sarah Powers-Barnhard are lending their voice to this effort. Ms. Powers-Barnhard is herself a survivor of abuse. She is advocating for the legislation so the voices of the abused children can be heard.

Attorney Jeff Herman supports legislation that does not shield predators. He is a staunch advocate for survivors of rape, sexual abuse, and sexual exploitation. As founder and manager of Herman Law located in Boca Rotan, Florida, Jeff and his team of attorneys have represented more than 1,000 clients. He has been featured on TV (CNN, Fox News, and MSNBC) and in print (New York Times, Miami New Times), bringing the issue of sexual predation out of the shadows. Sexual predators are shrouded in secrecy and silence, so by being vocal about the issue, Jeff advocates for victims who are often too afraid or intimidated to speak on their behalf. Jeff becomes their voice.

Jeff Herman and Herman Law have represented clients throughout the United States and Puerto Rico. In addition to fighting for victims in courts of law, he volunteers to provide professional development and training for other attorneys and law enforcement officers, and he has trained victim-witness liaisons on how to communicate effectively with victims of abuse.

Dr. David Samadi Says Choose Surgery Over Radiation

Based on scientific data, nearly 12 percent of men will be diagnosed with prostate cancer in the future. And when it comes to successfully treating the disease, Dr. David Samadi has a 90 percent success rate. For one, robotic surgery has brought significant progress, and Dr. Samadi is highly experienced in nerve sparing robotic prostatectomies.

Robotic Prostatectomy

The system itself consists of a console, where the surgeon sits, and the robot which has four arms. Through a small incision on the belly, the robotic instruments are brought into the body where Dr. Samadi guides the robot. On the screen the doctor can see a magnified three-dimensional image of the area. In the past decade, Dr. Samadi has performed more than 7000 of these surgeries.Dr. Samadi is Chief of Robotic Surgery at New York’s Lenox Hill Hospital, and he affirms that men undergoing prostate surgery have a better prognosis. In fact, studies show that men who underwent a surgical prostatectomy had lower mortality rates than those who chose other treatment methods. Additionally, studies confirm that just three months after the procedure, urinary incontinence and erectile dysfunction – the most common problems with prostate cancer, have significant function. And the proportion will increase significantly in the following months.

Worldwide, more than one million men are diagnosed with prostate cancer each year. Most choose to remove the tumor surgically, and patients even travel internationally to have Dr. David Samadi perform the surgery. In robotic-assisted surgery, patients lost less blood, stayed in the hospital for 1.7 days shorter, had less pain after one week and a better quality of life after six weeks.Dr. David Samadi is an award-winning, board-certified urologic oncologist. In addition to being an expert on laparoscopic radical prostatectomies, he’s been medical correspondent on FoxNews for the past seven years, and a broadcaster on his own half-hour program, Sunday Housecall, which airs Sundays at 12:30pm.Dr. Samadi joined Lenox Hill Hospital in 2013, developing a leading Urology program, and lending his expertise to international cancer causes.From 2008 to 2013, Dr. Samadi was honored with the Patient’s Choice Award. Those same years, he has also won American’s Top Doctor and American’s Best Doctor awards. In 2012 and 2013, he was named New York Metro Area’s Top Doctors.Dr. David Samadi received his undergraduate and medical degrees from Stony Brook University, New York.

Louis Chênevert Speak About the Mindset That Helped Him Lead United Technologies to the Forefront of Its Industry:

Louis R. Chênevert is a Canadian entrepreneur who had an extremely successful tenure as the CEO and Chairman of the Board at United Technologies Corporation. UTC builds the most advanced commercial and military jet engines in the world as well as being the world leader in the manufacture of elevators through their company Otis Elevator.

Louis holds a business administration degree from HEC Montreal as well as a pair of doctorate honoris causa awarded to him from HEC and Concordia University respectively. His long career in the business world has included time with General Motors and Pratt & Whitney Canada. He is known as a revolutionary thinker who truly understands the dynamics of the business world. During his tenure with United Technologies, the company not only survived in an ultra-competitive business market full of foreign competition and heavy regulations but has thrived and reached new heights of success.

Louis looked back on some of these accomplishments at United Technologies in a recent interview and gave his thoughts on what makes for successful entrepreneurship. He stressed that business is, firstly and foremostly, about understanding the customer’s needs and being able to delight them with your ability to meet those needs. Following this mantra and combining that with a true passion for innovating the most revolutionary products is what he believes made UTC so successful during his tenure at the top.

Major innovations in the areas of airplane and helicopter engine and body construction, the acquisition of Goodrich Aerospace and obtaining the rights to the next generation of Gulfstream G500 and G600 are seen by Louis as the major accomplishments realized by the company during his time as CEO and Chairman. His advice for entrepreneurs looking to obtain high levels of success revolves around being passionate and optimistic. Perhaps even more important, you must have the right team working for you. While Louis was at United Technologies he always focussed on operations and engineering talent and made sure that his people knew that they were appreciated. He believes that with this kind of ethic, combined with passion and optimism, you can overcome any of the obstacles that the business world throws at you.

Life Lessons From Dr. Saad

Dr. Saad is a highly experienced doctor with more than 40 years practicing in the profession. Aged 72, Dr. Saad specializes in pediatric and thoracic surgery. He is currently located at Eatontown in New Jersey.


Dr. Saad received his medical degree at Cairo University School of Medicine where he graduated in the year 1971. He served his residency as a general surgeon from UMDNJ University Hospital in the year 1977 and Medical University of SC in 1979. Dr. Saad has dealt with numerous surgery cases has received awards as a sign of the exemplary work he is able to perform. In 2014, he was awarded Patients’ Choice Award which is an award offered to physicians that have been able to satisfy their patients by offering quality support services. Dr. Saad also received Compassionate Doctor Recognition Award in the same year which is an award offered to physicians that demonstrated excellent bedside manner as they treat their patients.


The awards due to Dr. Saad are well awarded due to some of the patient reviews he has gotten over the years until the present. Most of his patients have been able to praise him for the excellent work he carried out while treating and operating them with a few exceptions where some slight misunderstanding may have cropped up.


Dr. Saad has also board certifications. The board certifications are for general surgery and pediatric surgery both from the Royal College of Physicians and Surgeons of Canada.




Key Life Lessons from Dr. Saad


After 47 years of practicing, Dr. Saad was able to retire, and left behind a legacy and valuable life lessons that one can borrow a leaf. The most important life lesson from Dr. Saad is learning to maintain resilience in pursuing one’s dreams and goals. Born a Palestinian in Israel at a time when there were many conflicts, Dr. Saad found himself having to relocate to a new conflict free zone at a very tender age together with his family. This environment assisted in building Dr. Saad into the man that he is currently by culturing endurance and flexibility at a young age.


Dr. Saad used this fortitude that was slowly being built in him to pursue high levels of education even though his background was not entirely in favor of this decision. His single focus and great belief that he could be anybody in the world strengthened his drive to pursuing his goals.


Dr. Saad’s main motivation to pursue becoming a surgeon came strongly to him when he suffered a heat stroke as a result of very hot conditions. His solace then became an operating room that was constantly air conditioned; hence his interest in becoming a surgeon grew more. Eventually, he has become a recognizable surgeon. Learn more:

Ricardo Tosto: Experienced Legal Representation In Brazil

Are you looking for quality representation in Brazil? If you are looking for a competent lawyer in Brazil, you need to check out Ricardo Tosto de Oliveira Carvalho. It is extremely important to hire good lawyer for business or corporate legal matter. Ricardo Tosto is a top attorney and has been rendering services for many years.

Legal matters are one reason companies often have a hard time succeeding. Because of this, a business litigation lawyer is an invaluable asset in helping a business or company run smoothly.

When you find yourself facing a business legal issue you need to hire the best lawyer you can afford. Mr Ricardo Tosto provides high quality advice and guidance to business and corporate clients.

Ricardo Tosto de Oliveira Carvalho is a leading business and corporate litigation attorney and he runs a prominent law firm in Brazil. As an experienced and reputable lawyer, Ricardo Tosto handles a wide variety of business legal matters, no matter how tough or simple the case may be, and his Website.

Business owners and corporate leaders today have many legal problems to deal with, including trademarks, copyrights, leases, collections, business disputes and even licensing. For this reason, enlisting the services of a good lawyer or law firm is important, and

If you’re searching for the right lawyer for your corporate or business legal issue, Ricardo Tosto is your clear choice. Ricardo Tosto has extensive knowledge of the rules and regulations affecting businesses. If you encounter any type of business legal problem, a good corporate or business lawyer like Ricardo Tosto can deliver the effective solutions for your situation, and what Ricardo Tosto knows.

Ricardo Tosto de Oliveira Carvalho is passionate about helping clients and he works closely with them to address the issue effectively. He has an established history of obtaining great outcomes for clients and his service will help improve your chances of getting a favorable outcome in your case.

By retaining a corporate or business litigation lawyer like Ricardo Tosto, you will avoid impending legal problems and realize many benefits of having an experienced and knowledgeable business lawyer on your side, and more information click here.

Jason Hope supporting SENS Research Foundation in anti-aging research

Jason Hope is an internet entrepreneur from Scottsdale, Arizona. He is known for his dedication to technological innovations. He follows closely technological innovations that are coming up lately and advises his followers on what to expect. Hope has a unique ability to tell which technological trend will be the next. Business people follow his analysis closely since they know him for giving accurate predictions on the development of technology. He is known for commentating about the Internet of Things which is a technology for the future. Jason Hope says that this will be the greatest technology development ever. It will be supported by the ability of electronic devices to connect to the internet and therefore can communicate with each other.

Another area that Jason Hope is concerned about is biotechnology. Biotechnology innovations are proving useful especially in finding human cure diseases. One application of biotechnology solutions is in developing anti-aging drugs. For a long time, humanity has applied a reactive approach to human needs as opposed to proactive. A solution to disease is only looked into after the disease has already affected people. As a people, we are concerned more with curative medicine as opposed to preventive medication. There are many age-related diseases which can be prevented if proper research work is applied. Conditions such as Alzheimer’s disease, cancer, and diabetes among others can be prevented.

Jason Hope being a technology expert realize the important role that biotechnology rejuvenation efforts would have in combating age-related diseases. He has dedicated his time and money in advocating for research in the field of biotechnology rejuvenations. His efforts in seeking for a solution to aging diseases are mainly focused on a nonprofit organization known as SENS Research Foundation. This is an organization that is developing a drug that will slow down the aging process in human beings.

SENS Research Foundation was formed in 2009 to come up with an AGE-Breaker drug specifically. This is a drug that would inhibit the production of aging causing substance in the human body. Jason Hope supported this group with a donation of $500,000. The group has used this money to set up a laboratory in Cambridge, England.

About Jason Hope

Jason Hope holds a Masters in Business Administration from W.P. Carey School of Business. He is a mentor in Scottsdale. He normally goes around the schools in the area mentoring young people on the importance of taking up technology. He is also a philanthropist who is supporting the education of brilliant but children from poor backgrounds.

Jason Hope info: